Clinical depression with its symptoms of despair, guilt, exhaustion, pain and anxiety is a debilitating condition. Severe sufferers struggle with a reason for living and some attempt suicide. Rising rates of teen suicide raises the alarm that depression is out of control and growing rapidly. It has been predicted by the World Health Organisation that by 2020 depression will be a greater threat to human health than heart disease or cancer.

Socially, this can be seen as a reaction to the current state of the world, uncertainty or pressure to perform. At a biochemical level it can be seen as an environmental and chemical crisis, causing an imbalance in brain chemistry. The effectiveness of antidepressant drugs indicates that neurochemistry is a major causal factor.

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